Metanx® is a prescription product indicated for the dietary management of homocysteine and endothelial dysfunction with particular emphasis in patients with diabetic peripheral neuropathy (DPN).
| L-methylfolate | 2.8mg |
| Pyridoxal 5'-phosphate | 25mg |
| Methylcobalamin | 2mg |
How Does Metanx® Work?
Every complication that develops in diabetes is related to circulatory disease, and nitric oxide plays a significant role in that process.
- Metanx® helps to improve circulation by increasing endogenous nitric oxide levels.1
Lack of protective sensation is the number one predictor of lower-extremity ulcerations and amputation.
- Metanx® has been shown to improve/restore protective sensation and vibratory sensation in patients with diabetic peripheral neuropathy (DPN).2
Elevated homocysteine is a significant risk factor for impaired wound healing in patients with chronic lower extremity ulcerations.
- Metanx® has been shown to effectively metabolize homocysteine in patients with chronic lower-extremity ulcerations and restore wound healing processes.3
The majority of painful DPN symptoms include numbness and tingling due to lack of sensation. Only 10-25% of patients with DPN experience painful symptoms. Current DPN therapies only target the painful symptoms while the underlying disease state progresses.
- Metanx® targets the underlying disease process and helps to improve sensation by increasing blood flow and supporting neurofunction as myelinogenesis and peripheral nerve repair.4,5
For more information on Metanx® and Diabetic Peripheral Neuropathy, click here.
For more information on Metanx® and Lower Extremity Ulcerations, click here.
To receive further information or free Metanx® samples, click here.
A medical food for the dietary management of endothelial dysfunction and/or hyperhomocysteinemia.
- Stroes ESC, et al. Folic Acid Reverts Dysfunction of Endothelial Nitric Oxide Synthase. Circulation Research. 2000;86:1129-1134.
- Vascular Disease Mangagement 2005;2 (Suppl 6):1S-9S.
- Boykin JV, Baylis C. Homocysteine--A Stealth Mediator of Impaired Wound Healing: A Preliminary Study. Wounds 2006;18(4):101-116.
- Yaqub, Basim A, et al. Effects of methylcobalamin on diabetic neuropathy. Clinical Neurology and Neurosurgery 1992;94:105-111.
- Devathasan G, et al. Methylcobalamin (CH3-B12;Methycobal) in Chronic Diabetic Neuropathy: A Double-Blind Clinical and Electrophysiological Study. Clinical Trials Journal 1986;23(2):130-140.
