1 National Diabetes Statistics fact sheet, NIDDK 2011. http://diabetes.niddk.nih.gov/dm/pubs/statistics/ 2 Parker JN, Parker PM. The Official Patient’s Sourcebook on Diabetic Neuropathy: A Revised and Updated Directory for the Internet Age. San Diego, CA:ICON Group International, Inc;2002:11-22. 3 Trippe, B. Diabetic Peripheral Neuropathy: The Forgotten Complication and New Therapeutic Approaches. Review of Endocrinology 2009; (Suppl):2-12. 4 Veves, Aristidis, et al. Endothelial Dysfunction and the Expression of Endothelial Nitric Oxide Synthetase in Diabetic Neuropathy, Vascular Disease, and Foot Ulceration. Diabetes 1998;47:457-463. 5 Walker MJ Jr, Morris LM. Increased cutaneous sensibility in patients with diabetic neuropathy utilizing a pharmacological approach–clinical case evidence. Clinical Case Update: Vascular Disease Management. 2007;2(1):1-8. 6 Abstracts of the 7th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology. Oral Presentations. Arterioscler Thromb Vasc Biol. 2006; 26: e43-e52.* 7 Argoff CE et al. Diabetic Peripheral Neuropathic Pain: Clinical and Quality-of-Life Issues. Mayo Clinic Proceedings April 2006;81(4 suppl):S3-S11. 8 Boulton AJM, et al. Diabetic Somatic Neuropathies. Diabetes Care 2004;27(6):1458-1486. 9Klerk M, et al. MTHFR 677CT Polymorphism and Risk of Coronary Heart Disease: A Meta Analysis. JAMA 2002;288:2023-2030. 10 Vinik Aaron. Diabetic Neuropathy: Pathogenesis and Therapy. The Am Journ of Med 1999;107(2B):17S-26S. 11Jacobs AM, Cheng D. Management of Diabetic Small-Fiber Neuropathy With Combination L-Methylfolate, Methylcobalamin, and Pyridoxal 5′ -Phosphate. Rev Neurol Dis 2011;8(1/2):39-47. 12Watanabe T, et al. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122:140-143. 13Walker M, et al. Improvement of Cutaneous Sensitivity in Diabetic Peripheral Neuropathy With Combination L-Methylfolate, Methylcobalamin, and Pyridoxal 5’ –Phosphate. Rev Neurol Dis 2010;7(4):132-139. 14Fonseca V, et al. Effect of Combination L-Methylfolate, Pyridoxal-5’-Phosphate, and Methylcobalamin on Neuropathy Symptoms and Inflammatory Biomarkers in Patients with Diabetic Peripheral Neuropathy (DPN). Diabetes July 2011;60(suppl 1):A289. 15Boulton AJM. Whither Clinical Research in Diabetic Sensorimotor Peripheral Neuropathy? Diabetes Care 2007;30(10):2752-2753. 16Tavakoli M, et al. Pathophysiology and Treatment of Painful Diabetic Neuropathy.Current Pain and Headache Reports 2008;12:192 17Ware, JE, et al. SF-36® Health Survey: Manual & Interpretation Guide. Lincoln, RI: QualityMetric Incorporated, 1993,2000. 18Obrosova IG, Watcho P, et al. Metanx Alleviates Diabetes-Induced Large and Small Fiber Neuropathies and Promotes Small Sensory Nerve Fiber Regeneration. Diabetes.2011;60 (Suppl 1): A179. 19 Tanenberg RJ. Diabetic Peripheral Neuropathy: Painful or Painless. Hospital Physician Nov/Dec 2009. 20 Adler AJ, et al. Lower-Extremity Ulceration in Diabetes. Diabetes Care 1999;22:1029-1035. 21Verhaar M.C., et al. 5-Methyltetrahydrofolate, the Active Form of Folic Acid, Restores Endothelial Function in Familial Hypercholesterolemia. Circulation 1998;97:237-241.
22van Etten R.W., et al. Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate. Diabetologia 2002;45:1004-1010.
23Romerio S.C., et al. Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults. Atherosclerosis 2004;176:337-344.
24Jacobs, Allen M. Abstracts of New Cardiovascular Horizons Meeting. Orally Administered L-methylfolate, Methylcobalamin, and pyridoxal 5’-phosphate Reduces the Symptoms of Diabetic Peripheral Neuropathy. Oral Presentations 2008.*
25Jacobs, Allen M. Abstracts of New Cardiovascular Horizons Meeting. L-methylfolate, methylcobalamin, and pyridoxal 5’ –phosphate supplementation to pregabalin partial responders for the treatment of painful diabetic neuropathy. Oral Presentations 2008.*
26Li G. Effect of Mecobalamin on Diabetic Neuropathies. Beijing Methycobal Clinical Trial Collaborative Group. Zhonghua Nei Ke Za Zhi 1999;38(1):14-17.
27Woo, KS, et al. Long-term Improvement in Homocysteine Levels and Arterial Endothelial Function after 1 Year Folic Acid Supplementation. The American Journal of Medicine 2002;112:535-539. 28Tanenberg RJ. Diabetic Peripheral Neuropathy: Painful or Painless. Hospital Physician 2009:1-8. 29Andrew Boulton, MD. “Diabetic Neuropathy Update: Oh the pain of it all.” Diabetic Foot & Ankle Symposium. Power Point Presentation. New CV Horizons, 7 September 2007. 30Frykberg RG, et al. Diabetic Foot Disorders: A Clinical Practice Guideline. The Journal of Foot & Ankle Surgery 2000;(suppl):2-60. 31The Diabetic Newsletter courtesy of NIDDK 2005.
References
1 National Diabetes Statistics fact sheet, NIDDK 2011. http://diabetes.niddk.nih.gov/dm/pubs/statistics/
2 Parker JN, Parker PM. The Official Patient’s Sourcebook on Diabetic Neuropathy: A Revised and Updated Directory for the Internet Age. San Diego, CA:ICON Group International, Inc;2002:11-22.
3 Trippe, B. Diabetic Peripheral Neuropathy: The Forgotten Complication and New Therapeutic Approaches. Review of Endocrinology 2009; (Suppl):2-12.
4 Veves, Aristidis, et al. Endothelial Dysfunction and the Expression of Endothelial Nitric Oxide Synthetase in Diabetic Neuropathy, Vascular Disease, and Foot Ulceration. Diabetes 1998;47:457-463.
5 Walker MJ Jr, Morris LM. Increased cutaneous sensibility in patients with diabetic neuropathy utilizing a pharmacological approach–clinical case evidence. Clinical Case Update: Vascular Disease Management. 2007;2(1):1-8.
6 Abstracts of the 7th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology. Oral Presentations. Arterioscler Thromb Vasc Biol. 2006; 26: e43-e52.*
7 Argoff CE et al. Diabetic Peripheral Neuropathic Pain: Clinical and Quality-of-Life Issues. Mayo Clinic Proceedings April 2006;81(4 suppl):S3-S11.
8 Boulton AJM, et al. Diabetic Somatic Neuropathies. Diabetes Care 2004;27(6):1458-1486.
9Klerk M, et al. MTHFR 677CT Polymorphism and Risk of Coronary Heart Disease: A Meta Analysis. JAMA 2002;288:2023-2030.
10 Vinik Aaron. Diabetic Neuropathy: Pathogenesis and Therapy. The Am Journ of Med 1999;107(2B):17S-26S.
11Jacobs AM, Cheng D. Management of Diabetic Small-Fiber Neuropathy With Combination L-Methylfolate, Methylcobalamin, and Pyridoxal 5′ -Phosphate. Rev Neurol Dis 2011;8(1/2):39-47.
12Watanabe T, et al. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 1994;122:140-143.
13Walker M, et al. Improvement of Cutaneous Sensitivity in Diabetic Peripheral Neuropathy With Combination L-Methylfolate, Methylcobalamin, and Pyridoxal 5’ –Phosphate. Rev Neurol Dis 2010;7(4):132-139.
14Fonseca V, et al. Effect of Combination L-Methylfolate, Pyridoxal-5’-Phosphate, and Methylcobalamin on Neuropathy Symptoms and Inflammatory Biomarkers in Patients with Diabetic Peripheral Neuropathy (DPN). Diabetes July 2011;60(suppl 1):A289.
15Boulton AJM. Whither Clinical Research in Diabetic Sensorimotor Peripheral Neuropathy? Diabetes Care 2007;30(10):2752-2753.
16Tavakoli M, et al. Pathophysiology and Treatment of Painful Diabetic Neuropathy.Current Pain and Headache Reports 2008;12:192
17Ware, JE, et al. SF-36® Health Survey: Manual & Interpretation Guide. Lincoln, RI: QualityMetric Incorporated, 1993,2000.
18Obrosova IG, Watcho P, et al. Metanx Alleviates Diabetes-Induced Large and Small Fiber Neuropathies and Promotes Small Sensory Nerve Fiber Regeneration. Diabetes.2011;60 (Suppl 1): A179.
19 Tanenberg RJ. Diabetic Peripheral Neuropathy: Painful or Painless. Hospital Physician Nov/Dec 2009.
20 Adler AJ, et al. Lower-Extremity Ulceration in Diabetes. Diabetes Care 1999;22:1029-1035.
21Verhaar M.C., et al. 5-Methyltetrahydrofolate, the Active Form of Folic Acid, Restores Endothelial Function in Familial Hypercholesterolemia. Circulation 1998;97:237-241.
22van Etten R.W., et al. Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate. Diabetologia 2002;45:1004-1010.
23Romerio S.C., et al. Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults. Atherosclerosis 2004;176:337-344.
24Jacobs, Allen M. Abstracts of New Cardiovascular Horizons Meeting. Orally Administered L-methylfolate, Methylcobalamin, and pyridoxal 5’-phosphate Reduces the Symptoms of Diabetic Peripheral Neuropathy. Oral Presentations 2008.*
25Jacobs, Allen M. Abstracts of New Cardiovascular Horizons Meeting. L-methylfolate, methylcobalamin, and pyridoxal 5’ –phosphate supplementation to pregabalin partial responders for the treatment of painful diabetic neuropathy. Oral Presentations 2008.*
26Li G. Effect of Mecobalamin on Diabetic Neuropathies. Beijing Methycobal Clinical Trial Collaborative Group. Zhonghua Nei Ke Za Zhi 1999;38(1):14-17.
27Woo, KS, et al. Long-term Improvement in Homocysteine Levels and Arterial Endothelial Function after 1 Year Folic Acid Supplementation. The American Journal of Medicine 2002;112:535-539.
28Tanenberg RJ. Diabetic Peripheral Neuropathy: Painful or Painless. Hospital Physician 2009:1-8.
29Andrew Boulton, MD. “Diabetic Neuropathy Update: Oh the pain of it all.” Diabetic Foot & Ankle Symposium. Power Point Presentation. New CV Horizons, 7 September 2007.
30Frykberg RG, et al. Diabetic Foot Disorders: A Clinical Practice Guideline. The Journal of Foot & Ankle Surgery 2000;(suppl):2-60.
31The Diabetic Newsletter courtesy of NIDDK 2005.