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Medical References
Patients with elevated homocysteine levels and cardiovascular disease have a distinct nutritional need for folate, vitamin B6 and vitamin B12. The following are published studies regarding the relationship between elevated homocysteine levels and increased cardiovascular risk.
MTHFR C––> T Polymorphism
Common Mutation in Methylenetetrahydrofolate Reductase
| Authors |
Deloughery, Thomas G., et al. |
| Publication |
Circulation 1996; 94:3074-3078 |
| Study Abstract |
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Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis
| Authors |
Wald, David S, et al. |
| Publication |
BMJ 2002;325:1202 |
| Study Abstract |
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MTHFR 677C––< T Polymorphism and Risk of Coronary Heart Disease
| Authors |
Klerk M, et al. |
| Publication |
JAMA 2002;288:2023-2030 |
| Study Abstract |
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Bioavailability
Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease
| Authors |
Willems, Frank F., et al. |
| Publication |
BMJ 2004; 141:825-830. |
| Study Abstract |
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Homocysteine & Cardiovascular Disease
Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamin B6 and B12
| Authors |
Till U, etal. |
| Publication |
Atherosclerosis 2005;181:131-135 |
| Study Abstract |
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Cost-effectiveness of vitamin therapy to lower plasma homocysteine levels for the prevention of coronary heart disease: effect of grain fortification and beyond
| Authors |
Tice JA, Ross E, Coxson PG, Rosenberg I, Weinstein MC, Hunink MG, Goldman PA, Williams L, Goldman L |
| Publication |
JAMA. 2001 Aug 22-29; 286(8) : 936-43 |
| Study Abstract |
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Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence
| Authors |
Eikelboom JW, Lonn E, Genest J Jr, Hankey G, Yusuf S |
| Publication |
Ann Intern Med. 1999 Sep 7; 131(5) : 363-75 |
| Study Abstract |
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Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease
| Authors |
Ottar Nygrd, M.D., Jan Erik Nordrehaug, M.D., Helga Refsum, M.D., Per Magne Ueland, M.D., Mikael Farstad, M.D., and Stein Emil Vollset, M.D., Dr.P.H |
| Publication |
N Engl J Med. 1997 Nov 27;337(22):1631-2; author reply 1632-3 |
| Study Abstract |
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Plasma total homocysteine levels and prognosis in patients with previous premature myocardial infarction
| Authors |
Retterstol L, Paus B, Bohn M, Bakken A, Erikssen J, Malinow MR, Berg K. |
| Publication |
J Intern Med. 2003 Mar; 253(3) : 284-92 |
| Study Abstract |
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What level of plasma homocyst(e)ine should be treated? Effects of vitamin therapy on progression of carotid atherosclerosis in patients with homocyst(e)ine levels above and below 14 -+?mol/L
| Authors |
Hackam DG, Peterson JC, Spence JD |
| Publication |
Am J Hypertens. 2000 Jan;13(1 Pt 1):105-10 |
| Study Abstract |
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Homocysteine & Diabetes
Factors Influencing Plasma Homocysteine Levels in Type 2 Diabetes
| Authors |
Passaro A, D.Elia K, Pareschi P, Calzoni F, Carantoni M, Fellin R, Solini A |
| Publication |
Diabetes Care, 2000 March; 23(3): 420-421 |
| Study Abstract |
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Homocysteine: an aetiological contributor to peripheral vascular arterial disease
| Authors |
Kuan YM, E Dear A, Grigg MJ |
| Publication |
ANZ J Surg. 2002 Sep; 72(9):668-71 |
| Study Abstract |
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Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey, 1988-1994
| Authors |
Lim U, Cassano PA |
| Publication |
Am J Epidemiol. 2002 Dec 15; 156(12):1105-13 |
| Study Abstract |
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Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis
| Authors |
Wald DS, Law M, Morris JK |
| Publication |
BMJ. 2002 Nov 23;325(7374):1202 |
| Study Abstract |
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Homocysteine and cardiovascular disease in diabetes mellitus
| Authors |
Audelin MC, Genest J Jr. |
| Publication |
Atherosclerosis. 2001 Dec; 159(2):497-511M |
| Study Abstract |
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Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes
| Authors |
Becker A, Kostense PJ, Bos G, Heine RJ, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD |
| Publication |
J Intern Med. 2003 Mar; 253(3):293-300 |
| Study Abstract |
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Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes: 5-year follow-up of the Hoorn Study
| Authors |
Hoogeveen EK, Kostense PJ, Jakobs C, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD |
| Publication |
Circulation. 2000 Apr 4;101(13):1506-11 |
| Study Abstract |
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Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study
| Authors |
Hoogeveen EK, Kostense PJ, Beks PJ, Mackaay AJ, Jakobs C, Bouter LM, Heine RJ, Stehouwer CD |
| Publication |
Arterioscler Thromb Vasc Biol. 1998 Jan; 18(1):133-8 |
| Study Abstract |
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Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn study
| Authors |
Hoogeveen EK, Kostense PJ, Eysink PE, Polak BC, Beks PJ, Jakobs C, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD |
| Publication |
Arch Intern Med. 2000 Oct 23; 160(19):2984-90 |
| Study Abstract |
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Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes
| Authors |
Emoto M, Kanda H, Shoji T, Kawagishi T, Komatsu M, Mori K, Tahara H, Ishimura E, Inaba M, Okuno Y, Nishizawa Y |
| Publication |
Diabetes Care. 2001 Mar; 24(3):533-8 |
| Study Abstract |
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Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate
| Authors |
van Etten RW, de Koning EJ, Verhaar MC, Gaillard CA, Rabelink TJ |
| Publication |
Diabetologia. 2002 Jul; 45(7):1004-10 |
| Study Abstract |
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Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus
| Authors |
Ambrosch A, Dierkes J, Lobmann R, Kuhne W, Konig W, Luley C, Lehnert H |
| Publication |
Diabet Med. 2001 Mar; 18(3):185-92 |
| Study Abstract |
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Endothelial Function
Effects of Oral Folic Acid Supplementation on Endothelial Function in Familial Hypercholesterolemia
| Authors |
Marianne C. Verhaar, MD; Robert M.F. Wever, PharmD; John J. P. Kastelein, MD, PhD; Douwe van Loon, PhD; Sheldon Milstein, PhD; Hein A. Koomans, MD, PhD; Ton J. Rabelink, MD, PhD |
| Publication |
Circulation. 1999; 100: 335-338 |
| Study Abstract |
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Folate Improves Endothelial Function in Coronary Artery Disease
| Authors |
Sagar N. Doshi, Ian F.W. McDowell, Stuart J. Moat, Derek Lang, Robert G. Newcombe, Mahmud B. Kredan, Malcolm J. Lewis, Jonathan Goodfellow |
| Publication |
Arterioscler Thromb Vasc Biol. 2001;21:1196-1202 |
| Study Abstract |
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Folic Acid Improves Endothelial Function in Coronary Artery Disease via Mechanisms Largely Independent of Homocysteine Lowering
| Authors |
Sagar N. Doshi, BSc MBChB; Ian F.W. McDowell, MD MRCP FRCPath; Stuart J. Moat, BSc PhD; Nicola Payne, BSc; Hilary J. Durrant, PhD MBChB MRCP; Malcolm J. Lewis, PhD DSc FESC; Jonathan Goodfello |
| Publication |
Circulation, 2001; 105:22-26 |
| Study Abstract |
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Improved Vascular Endothelial Function After Oral B Vitamins - An effect Mediated Through Reduced Concentrations of Free Plasma Homocysteine
| Authors |
John C. Chambers, MD; Per M. Ueland, MD; Omar A. Obeid, PhD; Jane Wrigley, RGN; Helga Refsum, MD; Jaspal S. Kooner, MD, FRCp |
| Publication |
Circulation. 2000; 102 : 2479-2483 |
| Study Abstract |
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Short-Term Oral Folic Acid Supplementation Enhances Endothelial Function in Patients With Type 2 Diabetes
| Authors |
Arduino A. Mangoni, Roy A. Sherwood, Belinda Asonganyi, Cameron G. Swift, Stephen Thomas, and Stephen H.D. Jackson |
| Publication |
American Journal of Hypertension; 2005;18:220-226. |
| Study Abstract |
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Medications that increase Homocysteine
Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term?
| Authors |
Griffith SM, Fisher J, Clarke S, Montgomery B, Jones PW, Saklatvala J, Dawes PT, Shadforth MF, Hothersall TE, Hassell AB, Hay EM. |
| Publication |
Rheumatology (Oxford). 2000 Oct;39(10):1102-9 |
| Study Abstract |
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Drugs affecting homocysteine metabolism: impact on cardiovascular risk
| Authors |
Desouza C, Keebler M, McNamara DB, Fonseca V. |
| Publication |
Drugs. 2002; 62(4): 605-16. |
| Study Abstract |
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Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial
| Authors |
Wulffele MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, Donker AJ, Stehouwer CD |
| Publication |
J Intern Med. 2003 Nov; 254(5): 455-63 |
| Study Abstract |
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Folate Supplementation Prevents Plasma Homocysteine Increase After Fenofibrate Therapy
| Authors |
Thomas Stulc, MD; Vojitech Melenovsky, MD; Barbora Grauova, MD, PhD; Viktor Kozich, MD, PhD; and Richard Ceska, MD, PdD |
| Publication |
Nutrition. 2001 Sep; 17(9): 721-3 |
| Study Abstract |
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Niacin Treatment Increases Plasma Hcy Levels
| Authors |
Rekha Garg, MD, MS; M. Rene Malinow, MD; Mary Pettinger, MS; Barbara Upson, BS; Donald Hunninghake, MD |
| Publication |
American Heart Journal. 1999 Dec, part 1; 138(6) |
| Study Abstract |
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Homocysteine and Diabetic Neuropathy
Short-Term Oral Folic Acid Supplementation Enhances Endothelial Function in Patients With Type 2 Diabetes
| Authors |
Arduino A. Mangoni, Roy A. Sherwood, Belinda Asonganyi, Cameron G. Swift, Stephen Thomas, and Stephen H.D. Jackson |
| Publication |
American Journal of Hypertension; 2005;18:220-226. |
| Study Abstract |
Download PDF |
Effects of methylcobalamin on diabetic neuropathy
| Authors |
Basim A. Yaqub, Abdulaziz Siddiqueb and Riad Sulimani |
| Publication |
Clinical Neurology and Neurosurgery, 94 (1992) I05-111 |
| Study Abstract |
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Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus
| Authors |
A. Ambrosch, J. Dierkes, R. Lobmann, W. K++hne, W. K++?nig, C. Luley and H. Lehnert |
| Publication |
Diabet. Med. 18, 185-192 (2001) |
| Study Abstract |
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