L-methylfolate is directly involved in HCY Metabolism

Folic Acid Must Complete a 4 Step Conversion Process.

There are 4 separate biochemical reactions required to convert supplemental folic acid into L-methylfolate:

1. In the process of intestinal absorption and subsequent transfer into peripheral tissue, folic acid is converted into Dihydrofolate (DHF) by the Dihydrofolate Reductase enzyme (DHFR).
2. DHF is then metabolized into Tetrahydrofolate (THF) again by DHFR.
3. THF is metabolized into 5,10-Methylene-THF.
4. 5,10-Methylene-THF is converted to L-methylfolate by the Methyltetrahydrofolate Reductase enzyme (MTHFR).

No conversion required with L-methylfolate.

1. L-methylfolate is the bioavailable form of folate directly involved in homocysteine metabolism.